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Silk-elastin-like protein biomaterials for the controlled delivery of therapeutics.

Expert Opin Drug Deliv. 2015-05; 
HuangWenwen,RollettAlexandra,KaplanDav
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Biochemicals CA) and GenScript (Piscataway Get A Quote

摘要

Genetically engineered biomaterials are useful for controlled delivery owing to their rational design, tunable structure-function, biocompatibility, degradability and target specificity. Silk-elastin-like proteins (SELPs), a family of genetically engineered recombinant protein polymers, possess these properties. Additionally, given the benefits of combining semi-crystalline silk-blocks and elastomeric elastin-blocks, SELPs possess multi-stimuli-responsive properties and tunability, thereby becoming promising candidates for targeted cancer therapeutics delivery and controlled gene release.

关键词

drug delivery,gene delivery,hydrogel,nanoparticle,protein,self-assembly,silk-elastin,stimuli respon
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