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Pharmacological targeting of CXCL12/CXCR4 signaling in prostate cancer bone metastasis.

Mol. Cancer. 2016-11; 
Conley-LaCombM Katie,SemaanLouie,SingareddyRajareddy,LiYanfeng,HeathElisabeth I,KimSeongho,CherMichael L,ChinniSreeniva
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Catalog Antibody … Immunoblot was performed with antibodies against pHER2 (Y1248) (Catalog # A00318-100, GenScript, Piscataway, NJ), total HER2 (Catalog #, SC-284, Santa Cruz Biotechnology, Dallas, TX) pEGFR (Y1173) (Catalog # 4407 s, Cell Signaling, Beverly, MA), total EGFR … Get A Quote

摘要

The CXCL12/CXCR4 axis transactivates HER2 and promotes intraosseous tumor growth. To further explore the transactivation of HER2 by CXCL12, we investigated the role of small GTP protein G in Src and HER2 phosphorylation in lipid raft membrane microdomains and the significance of CXCR4 in prostate cancer bone tumor growth.

关键词

Bone metastasis,CXCR4,CXL12,EGFR,Gefitinib,HER2,Plerixafor
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