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The most abundant cyst wall proteins of Acanthamoeba castellanii are lectins that bind cellulose and localize to distinct structures in developing and mature cyst walls.

PLoS Negl Trop Dis. 2019; 
Magistrado-CoxenPamela，AqeelYousuf，LopezAngelo，HaserickJohn R，UrbanowiczBreeanna R，CostelloCatherine E，Samuelson
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Codon Optimization … A GST-AcCBM49 fusion-construct, which contains the N-terminal CBM49 of an abundant Luke lectin minus the signal peptide, was prepared by codon optimization (76 to 330-bp coding region of ACA1_377670) (S1 Fig and S1 Excel file) (GenScript, Piscataway, NJ) … Get A Quote

摘要

Acanthamoeba castellanii， which causes keratitis and blindness in under-resourced countries， is an emerging pathogen worldwide， because of its association with contact lens use. The wall makes cysts resistant to sterilizing reagents in lens solutions and to antibiotics applied to the eye.

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