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Mechanism of CK2.3, a Novel Mimetic Peptide of Bone Morphogenetic Protein Receptor Type IA, Mediated Osteogenesis.

Int J Mol Sci. 2019-05; 
VrathashaVrathasha,WeidnerHilary,Nohe
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Peptide Synthesis CK2.3 (1.915 μM) is a custom designed osteogenic peptide synthesized at GenScript (Piscataway, NJ, USA). Get A Quote

摘要

Osteoporosis is a degenerative skeletal disease with a limited number of treatment options. CK2.3, a novel peptide, may be a potential therapeutic. It induces osteogenesis and bone formation in vitro and in vivo by acting downstream of BMPRIA through releasing CK2 from the receptor. However, the detailed signaling pathways, the time frame of signaling, and genes activated remain largely unknown.

关键词

BMP2,CK2,CK2.3,RT-qPCR,bone,osteogenesis,osteogenic signal transduction,osteoporosis,western b
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