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Metformin sensitizes hypoxia-induced gefitinib treatment resistance of HNSCC via cell cycle regulation and EMT reversal.

Cancer Manag Res. 2018; 
YinXiteng，WeiZheng，SongChuanhui，TangChuanchao，XuWenguang，WangYufeng，XieJunqi，LinZitong，Ha
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Recombinant Proteins Protein samples were mixed with 5× loading buffer (GenScript, Nanjing, China) and heated at 95°C for 10 minutes. Get A Quote

摘要

The objectives of this study were to explore the mechanisms of metformin sensitization to hypoxia-induced gefitinib treatment in resistant head and neck squamous cell carcinoma (HNSCC) and evaluate the effects of this combined treatment strategy.

关键词

gefitinib resistance，metformin，tumor hyp
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