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The New Plant Expression System for the Development of Vaccines against Papillomaviruses.

Dokl. Biochem. Biophys.. 2019-05; 
SalyaevR K，RekoslavskayaN I，Stolbiko
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Custom Vector Construction The integration of the genetic constructs for nuclear transformation of tomato plants into the pBINPLUS/ARS vector and the synthesis according to our design were implemented at the Genscript company (United States). Get A Quote

摘要

To enhance the synthesis of antigenic envelope proteins L1 of high-grade papillomavirus types HPV16， HPV18， HPV31， and HPV45， the sequence of the gene encoding the cucumber mosaic virus replicase (RdRP CMV) was inserted into the genetic construct. This made it possible to increase the production of these antigenic proteins to 25-27 μg/mg total soluble protein.

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