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Anti-NT5C1A autoantibodies are associated with more severe disease in patients with juvenile myositis.

Ann. Rheum. Dis.. 2018;

YekerRichard M，Pinal-FernandezIago，KishiTakayuki，PakKatherine，TargoffIra N，MillerFrederick W，RiderLisa G，MammenAndre

Products/Services Used	Details	Operation
Peptide Synthesis	… Full‐length, purified recombinant N‐terminal His‐tagged cN1A protein (NCBI RefSeq NP_115915.1) was obtained (GenScript USA, Piscataway, NJ), and three 36‐amino acid cN1A peptides and a control cN1B/NT5C1B peptide were synthesized commercially (Elim …	Get A Quote

摘要

Autoantibodies recognising cytosolic 5'-nucleotidase 1A (NT5C1A) are found in adult patients with myositis and other autoimmune diseases. They are especially prevalent in adults with inclusion body myositis (IBM)， in which they are associated with more severe weakness and higher mortality. This study was undertaken to define the prevalence and clinical features associated with anti-NT5C1A autoantibodies in juvenile myositis.