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The epigenetic modification during the induction of Foxp3 with sodium butyrate.

Immunopharmacol Immunotoxicol. 2018;

CaoTengli，ZhangXiuxiu，ChenDingding，ZhangPeiyan，LiQing，MuhammadA

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Peptide Synthesis	… In brief, 8-10 week old female mice were immunized at the base of the tail and in both thighs with 200 μg of mouse MOG3555 peptide (custom synthesized by GenScript USA Inc., Piscataway, NJ) emulsified in Complete Freund's Adjuvant (CFA) (Difco Laboratories, Inc., Detroit …	Get A Quote

摘要

CD4 + CD25+ regulatory T (Treg) lymphocytes are critical for immune homeostasis. Foxp3 (Forkhead Box protein P3) is always considered as a marker of function and identities determination of Treg cells because of special occurring in Treg cell. People who lack Treg cells or have a low expression of Foxp3 gene will suffer fatal autoimmunity. Scientists are trying to use Treg cells as a treatment for autoimmune disease， such as systemic lupus erythematosus.