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Transdermal Delivery of AT1 Receptor Antagonists Reduce Blood Pressure and Reveal a Vasodilatory Effect on Kidney Blood Vessels.

Curr Mol Pharmacol. 2018;

MichalatouMichaila，AndroutsouMaria Eleni，AntonopoulosMarkos，VlahakosDemetrios V，AgelisGeorge，ZulliAnthony，QaradakhiTawar，MikkelsenKathleen，ApostolopoulosVasso，Matsoukas

Products/Services Used	Details	Operation
Peptide Synthesis	… LP-12, HIITDPNMAEYL, 4.18, − 1.9, 25%, 50%, 1416.62. 2. Materials and methods. 2.1. Chemicals. The peptides were chemically synthesized by Genscript Inc. (Piscataway, NJ, USA). Cyclosporine A (CsA) was purchased from Abcam (Cambridge, MA, USA) …	Get A Quote

摘要

The Renin Angiotensin System (RAS) is pharmacologically targeted to reduce blood pressure， and patient compliance to oral medications is a clinical issue. The mechanisms of action of angiotensin receptor blockers (ARBs) in reducing blood pressure are not well understood and are purported to be via a reduction of angiotensin II signaling.