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The natural polyphenol curcumin induces apoptosis by suppressing STAT3 signaling in esophageal squamous cell carcinoma.

J. Exp. Clin. Cancer Res.. 2018; 
LiuYing,WangXinhua,ZengShuang,ZhangXiane,ZhaoJimin,ZhangXiaoyan,ChenXinhuan,YangWanjing,YangYili,DongZiming,ZhuJingyu,XuXin,Tian
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摘要

We and others have previously shown that the STAT3 signaling pathway is activated in some esophageal squamous cell carcinoma (ESCC) cells and is required for the survival and growth of these primary ESCC-derived xenografts. It has also been shown that the natural polyphenol curcumin is an effective anti-tumor agent.

关键词

Apoptosis,Curcumin,Esophageal squamous cell carcinoma,PDX model,S
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