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Pathogenic Citrulline-Multispecific B Cell Receptor Clades in Rheumatoid Arthritis.

Arthritis Rheumatol. 2018;

Titcombe Philip J，Wigerblad Gustaf，Sippl Natalie，Zhang Na，Shmagel Anna K，Sahlstr?m Peter，Zhang Yue，Barsness Laura O，Ghodke-Puranik Yogita，Baharpoor Azar，Hansson Monika，Israelsson Lena，Skriner Karl，Niewold Timothy B，Klareskog Lars，Svensson Camilla I，Amara Khaled，Malmstr?m Vivianne，Mueller Dani

Products/Services Used	Details	Operation
Peptide Synthesis	-terminal biotin moiety, were custom ordered from GenScript. Peptides (>95% purity) were reconstituted	Get A Quote

摘要

Anti-citrullinated protein antibodies (ACPAs) have proven highly useful as biomarkers for rheumatoid arthritis (RA). However， composition and functionality of the associated autoreactive B cell repertoire have not been directly assessed. We aimed to selectively investigate citrullinated autoantigen-specific B cell receptors (BCRs) involved in RA and initiate studies on their pathogenicity.