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DKK3 (Dickkopf 3) Alters Atherosclerotic Plaque Phenotype Involving Vascular Progenitor and Fibroblast Differentiation Into Smooth Muscle Cells.

Arterioscler. Thromb. Vasc. Biol.. 2018;

Karamariti Eirini，Zhai Chungang，Yu Baoqi，Qiao Lei，Wang Zhihong，Potter Claire M F，Wong Mei Mei，Simpson Russell M L，Zhang Zhongyi，Wang Xiaocong，Del Barco Barrantes Ivan，Niehrs Christof，Kong Deling，Zhao Qiang，Zhang Yun，Hu Yanhua，Zhang Cheng，Xu Qi

Products/Services Used	Details	Operation
Recombinant Proteins	-active-b-catenin, SMA (Sigma, 05-665; A5228), Calponin (Abcam, ab46794), mouse DKK3 (GenScript, custom	Get A Quote

摘要

DKK3 (dickkopf 3)， a 36-kD secreted glycoprotein， has been shown to be involved in the differentiation of partially reprogrammed cells and embryonic stem cells to smooth muscle cells (SMCs)， but little is known about its involvement in vascular disease. This study aims to assess the effects of DKK3 on atherosclerotic plaque composition.