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Phosphate Starvation-Dependent Iron Mobilization Induces CLE14 Expression to Trigger Root Meristem Differentiation through CLV2/PEPR2 Signaling.

Dev. Cell. 2017;

Gutiérrez-Alanís Dolores，Yong-Villalobos Lenin，Jiménez-Sandoval Pedro，Alatorre-Cobos Fulgencio，Oropeza-Aburto Araceli，Mora-Macías Javier，Sánchez-Rodríguez Federico，Cruz-Ramírez Alfredo，Herrera-Estrella

Products/Services Used	Details	Operation
Peptide Synthesis	/A Chemicals, Peptides, and Recombinant Proteins synthetic CLE14 peptide Genscript N/A Critical Commercial	Get A Quote

摘要

Low inorganic phosphate (Pi) availability causes terminal differentiation of the root apical meristem (RAM)， a phenomenon known as root meristem exhaustion or determined growth. Here， we report that the CLE14 peptide acts as a key player in this process. Low Pi stress induces iron mobilization in the RAM through the action of LPR1/LPR2， causing expression of CLE14 in the proximal meristem region. CLV2 and PEPR2 receptors perceive CLE14 and trigger RAM differentiation， with concomitant downregulation of SHR/SCR and PIN/AUXIN pathway. Our results reveal multiple steps of the molecular mechanism of one of the most physiologically important root nutrient responses.