Sphingosine-1-phosphate (S1P) is a vasoprotective lipid mediator. About two thirds of plasma S1P rides on high-density lipoprotein (HDL)， and several pleiotropic properties of HDL have been ascribed to S1P. In human subjects， CETP (cholesteryl ester transfer protein) greatly influences HDL quantities. In this study， we attempted to elucidate the roles of CETP in the metabolism of S1P.
Sphingosine-1-phosphate (S1P) is a vasoprotective lipid mediator. About two thirds of plasma S1P rides on high-density lipoprotein (HDL)， and several pleiotropic properties of HDL have been ascribed to S1P. In human subjects， CETP (cholesteryl ester transfer protein) greatly influences HDL quantities. In this study， we attempted to elucidate the roles of CETP in the metabolism of S1P.
