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Depression and synaptic zinc regulation in Alzheimer disease， dementia with lewy bodies， and Parkinson disease dementia.

Am J Geriatr Psychiatry. 2015;

Whitfield David R，Vallortigara Julie，Alghamdi Amani，Hortobágyi Tibor，Ballard Clive，Thomas Alan J，O'Brien John T，Aarsland Dag，Francis Pa

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Proteins, Expression, Isolation and Analysis	Western Blotting The homogenate was boiled for 5 minutes in 5x sample buffer (Genscript MB01015) prior to storage at -20 °C.	Get A Quote

摘要

Depression is a common symptom in dementia with Lewy bodies (DLB)， Parkinson disease dementia (PDD)， and Alzheimer disease (AD)， yet its molecular basis remains unclear and current antidepressants do not appear to be effective. Cerebral zinc has been implicated in depression and synaptic dysfunction. We investigated the relationship between synaptic zinc regulation (for which zinc transporter 3 [ZnT3] is responsible) and depression in a large clinicopathologic study.