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MiR-137 and miR-34a directly target Snail and inhibit EMT, invasion and sphere-forming ability of ovarian cancer cells.

J. Exp. Clin. Cancer Res.. 2016; 
Dong Peixin,Xiong Ying,Watari Hidemichi,Hanley Sharon J B,Konno Yosuke,Ihira Kei,Yamada Takahiro,Kudo Masataka,Yue Junming,Sakuragi Nor
Products/Services Used Details Operation
Catalog Antibody Equal amounts of protein lysates (30 μg) were separated by 10 % SDS -PAGE for immunoblots with antibodies to Snail (Abcam), E-cadherin (GenScript), N-cadherin (BD Biosciences), Vimentin (GenScript) and GAPDH (Santa Cruz). Get A Quote

摘要

In ovarian cancer (OC) cells, Snail was reported to induce the epithelial-to-mesenchymal transition (EMT), which is a critical step in OC metastasis. At present little is known about controlling Snail expression in OC cells by using specific microRNAs (miRNAs).

关键词

Cancer stemness,EMT,Ovarian cancer,Snail,microRNA-137,microRNA
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