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Lysosome-associated membrane protein-2 deficiency increases the risk of reactive oxygen species-induced ferroptosis in retinal pigment epithelial cells.

Biochem Biophys Res Commun. 2020;

Lee JJ1, Ishihara K2, Notomi S3, Efstathiou NE2, Ueta T2, Maidana D2, Chen X2, Iesato Y2, Caligiana A2, Vavvas DG4.

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Recombinant Proteins	… min. Equal amounts of protein samples were separated on a 4–12% SDS-PAGE Bis-Tris gel (Thermo Fisher) and transferred to PVDF membranes (MilliporeSigma) on a semidry blotting system (GenScript, Piscataway, NJ). Equal …	Get A Quote

摘要

Lysosome-associated membrane protein-2 (LAMP2), is a highly glycosylated lysosomal membrane protein involved in chaperone mediated autophagy. Mutations of LAMP2 cause the classic triad of myopathy, cardiomyopathy and encephalopathy of Danon disease (DD). Additionally, retinopathy has also been observed in young DD patients, leading to vision loss. Emerging evidence show LAMP2-deficiency to be involved in oxidative stress (ROS) but the mechanism remains obscure. In the present study, we found that tert-butyl hydroperoxide or antimycin A induced more cell death in LAMP2 knockdown (LAMP2-KD) than in control ARPE-19 cells. Mechanistically, LAMP2-KD reduced the concentration of cytosolic cysteine, resulting in low g... More