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Carbon black nanoparticles induce pulmonary fibrosis through NLRP3 inflammasome pathway modulated by miR-96 targeted FOXO3a.

Chemosphere. 2020; 
Zhou L1, Li P1, Zhang M1, Han B1, Chu C1, Su X1, Li B2, Kang H2, Ning J1, Zhang B1, Ma S2, Su D2, Pang Y1, Niu Y3, Zhang R4.
Products/Services Used Details Operation
Cellular Analysis … Beckman coulter, CA, USA). Detection for endotoxin of the CB particles was carried
out with Toxin SensorTM Chromogenic LAL Endotoxin Assay Kit (Genscript, NJ,
USA) following the manufacturer's protocol. It based on the …
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摘要

Carbon black nanoparticle (CBNP) is a core constituent of air pollutants like fine particulate matter (PM2.5) as well as a common manufactural material. It was proved to pose adverse effects on lung function and even provoke pulmonary fibrosis. However, the underlying mechanisms of CBNPs-induced pulmonary fibrosis remain unclear. The present study aimed to investigate the mechanism of fibrotic effects caused by CBNPs in rat lung and human bronchial epithelial (16HBE) cells. Forty-nine male rats were randomly subjected to 7 groups, means the 14-day exposure group (30 mg/m3), the 28-day exposure groups (5 mg/m3 and 30 mg/m3), the 90-day exposure group (30 mg/m3) and their respective controls. Rats were no... More

关键词

Carbon black nanoparticles (CBNPs); FOXO3a; NLRP3 inflammasome; Pulmonary fibrosis; miR-96
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