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Lactobacillus plantarum induces genomic DNA-dependent and TLR9-mediated elafin secretion from Caco-2 cells.

Asian Pac. J. Allergy Immunol.. 2019; 
HiramatsuYukihiro，SakamotoDaisuke，SathoTomomitsu，IrieKeiichi，MiakeFumio，MaedaMinoru，KashigeNobu
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Peptide Synthesis The 143 peptides of TH023 were kindly provided by the Natural and Medical Sciences Institute (University of TÜbingen, Germany) and 25 peptides of CM240 were commercially synthesized (GenScript, Piscataway, NJ, USA). Get A Quote

摘要

Lactobacilli show anti-inflammatory effects in the human intestine， and their genomic DNA was identified as one of the anti-inflammatory components. Increased levels of the natural protease inhibitor elafin in the intestine plays an important role in protection against intestinal inflammation. However， there have been no previous reports regarding whether lactobacilli increase elafin levels.

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