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Fibril Charge Affects α-Synuclein Hydrogel Rheological Properties.

Langmuir. 2019; 
Pogostin BH, Linse S, Olsson U.
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摘要

In this paper, we have investigated the interactions between α-synuclein fibrils at different pH values and how this relates to hydrogel formation and gel properties. Using a combination of rheology, small-angle X-ray scattering, Raman spectroscopy, and cryo-transmission electron microscopy (cryo-TEM) experiments, we have been able to investigate the relationship between protein net charge, fibril-fibril interactions, and hydrogel properties, and have explored the potential for α-synuclein to form hydrogels at various conditions. We have found that α-synuclein can form hydrogels at lower concentrations (50-300 μM) and over a wider pH range (6.0-7.5) than previously reported. Over this pH range and at 300 μ... More

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