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Spatiotemporally Skewed Activation of Programmed Cell Death Receptor 1-Positive T Cells after Epstein-Barr Virus Infection and Tumor Development in Long-Term Fully Humanized Mice.

Am J Pathol. 2019; 
Danisch S, Slabik C, Cornelius A, Albanese M, Tagawa T, Chen YA, Krönke N, Eiz-Vesper B, Lienenklaus S, Bleich A, Theobald SJ, Schneider A, Ganser A, von Kaisenberg C, Zeidler R, Hammerschmidt W, Feuerhake F, Stripecke R.
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Codon Optimization … 22 EBV-B958/firefly luciferase 2 (fLuc2) was derived from the EBV-B958/GFP strain and contains a codon-optimized fLuc cDNA (luc2; Genscript Biotech, Piscataway Township, NJ) coupled to a preceding T2A element and engineered to be expressed downstream of the viral … Get A Quote

摘要

Humanized mice developing functional human T cells endogenously and capable of recognizing cognate human leukocyte antigen-matched tumors are emerging as relevant models for studying human immuno-oncology in vivo. Herein, mice transplanted with human CD34+ stem cells and bearing endogenously developed human T cells for >15 weeks were infected with an oncogenic recombinant Epstein-Barr virus (EBV), encoding enhanced firefly luciferase and green fluorescent protein. EBV-firefly luciferase was detectable 1 week after infection by noninvasive optical imaging in the spleen, from where it spread rapidly and systemically. EBV infection resulted into a pronounced immunologic skewing regarding the expansion of CD8+ T ... More

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