资源 » 参考数据库 » 客户发表文献

至今，GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次，处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果，再次证明GenScript 有能力帮助业内科学家Make research easy.

Innate Lymphoid Cells Play a Pathogenic Role in Pericarditis

Cell Rep. 2020;

Choi HS, Won T, Hou X, Chen G, Bracamonte-Baran W, Talor MV, Jurčová I, Szárszoi O, Čurnova L, Stříž I, Hooper JE, Melenovský V, Čiháková D.

Products/Services Used	Details	Operation
Peptide Synthesis	Cat#00409662902 CellTrace Violet Cell Proliferation Kit Thermo Fisher Cat#C34557 CellTrace Far Red Cell Proliferation Kit Thermo Fisher Cat#C34564 MyHCa614-629 (Ac-SLKLMATLFSTYASAD) Trilogy GenScript N/A Cell Marque Cat#920P-04 TBS with Tween (TBST), 20X Solution Thermo Fisher Cat#J75500-K2 Dual Endogenous Enzyme Block Dako Cat#S2003 Antibody Dilution Buffer Ventana Cat#ADB250 Richard-Allan Scientiﬁc Signature Series Hematoxylin 1 Thermo Fisher Cat#7221 Richard-Allan Scientiﬁc Signature Series Clear-Rite 3 Thermo Fisher Cat#6901 Shandon Bluing Reagent Thermo Fisher Cat#6769001 Optic Mount I Toluene Mercedes Scientiﬁc Cat#MER7722 Maxpar PBS Fluidigm Cat#201058 Cell-ID Intercalator-Ir Fluidigm Cat#201192B Cell-ID Cisplatin Fluidigm Cat#201064 Maxpar Cell Staining Buffer Fluidigm Cat#201068 Maxpar Fix and Perm Buffer Fluidigm Cat#201067 16% Formaldehyde (w/v), Methanol-free Thermo Fisher Cat#28906 Critical Commercial Assays Mouse CCL11/Eotaxin-1 Quantikine ELISA Kit R&D Systems Cat#MME00 Anti-Goat HRP-DAB Cell & Tissue Staining Kit R&D Systems Cat#CTS008 Experimental Models: Organisms/Strains Mouse: WT: BALB/cJ Mouse: CD45....5 mg/well myosin heavy chain a peptide MyHCa614-629 (Ac-SLKLMATLFSTYASAD; Genscript) and Alkaline Phosphatase AfﬁniPure goat anti-mouse IgM, m chain speciﬁc (Jackson ImmunoResearch) at a 1:4000 dilution was used to detect anti-myosin IgM in sera.	Get A Quote

摘要

We find that cardiac group 2 innate lymphoid cells (ILC2s) are essential for the development of IL-33-induced eosinophilic pericarditis. We show a pathogenic role for ILC2s in cardiac inflammation, in which ILC2s activated by IL-33 drive the development of eosinophilic pericarditis in collaboration with cardiac fibroblasts. ILCs, not T and B cells, are required for the development of pericarditis. ILC2s transferred to the heart of Rag2-/-Il2rg-/- mice restore their susceptibility to eosinophil infiltration. Moreover, ILC2s direct cardiac fibroblasts to produce eotaxin-1. We also find that eosinophils reside in the mediastinal cavity and that eosinophils transferred to the mediastinal cavity of eosinophil-defici... More