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N-terminal [Glu] moiety of γ-glutamyl peptides contributes largely to the activation of human calcium-sensing receptor, a receptor

Biosci Biotechnol Biochem. 2020-03-01; 
Mizuki Yamamoto, Yuko Terada, Takayasu Motoyama, Munehisa Shibata, Tsutomu Saito, Keisuke Ito
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Recombinant Proteins … The following materials were used in this study: γ-Glu-Ala was purchased from Anygen Co., Ltd. (Jangseong-gun, Korea); and γ-[Glu] (n=1,2,3,4) -Tyr, γ-Glu-α-[Glu] (n=1,2,3) -Tyr, and α-Glu-Tyr from GenScript Japan Inc. (Tokyo, Japan) … Get A Quote

摘要

γ-glutamyl peptides have been suggested to impart properties to foods by activating human calcium-sensing receptor (hCaSR). In this study, the relationship between γ-glutamyl peptide structure and hCaSR activity was systematically analyzed using γ-[Glu]-α-[Glu]-Tyr. Our results suggest that N-terminal [Glu] moiety is very important for hCaSR activities of γ-glutamyl peptides.

关键词

kokumi, calcium-sensing receptor, gamma-glutamyl peptide, structure-activity relationship study
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