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STAC proteins: The missing link in skeletal muscle EC coupling and new regulators of calcium channel function

Biochim Biophys Acta Mol Cell Res. 2018-12-01; 
Bernhard E Flucher, Marta Campiglio
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Peptide Synthesis … mRNA transcript 1 (NP003140.1), mouse stac2 (NP666140.1), and human stac3 isoform 2 (NP659501.1). U-peptide was synthesized by Genscript (KVDPVYETLRYGTSLALMNRSS) … RyR1 P2 domain was synthesized by Genscript (sequence in Supplementary Table 2.1) … Get A Quote

摘要

Excitation-contraction coupling is the signaling process by which action potentials control calcium release and consequently the force of muscle contraction. Until recently, three triad proteins were known to be essential for skeletal muscle EC coupling: the voltage-gated calcium channel Ca1.1 acting as voltage sensor, the SR calcium release channel RyR1 representing the only relevant calcium source, and the auxiliary Ca β subunit. Whether Ca1.1 and RyR1 are directly coupled or whether their interaction is mediated by another triad protein is still unknown. The recent identification of the adaptor protein STAC3 as fourth essential component of skeletal muscle EC coupling prompted vigorous research to reveal it... More

关键词

Ca(V)1.1, Calcium channels, Calcium-dependent inactivation, Ryanodine receptor, STAC3, Skeletal muscle excitation-contraction coupling
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