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Structural basis for multifunctional roles of mammalian aminopeptidase N

Proc Natl Acad Sci U S A. 2012-10-01; 
Lang Chen, Yi-Lun Lin, Guiqing Peng, Fang Li
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Recombinant Proteins … Besides its above functions, APN is also the receptor for several coronaviruses such as … Liu C*, Tang J*, Ma Y*, Liang X, Yang Y, Peng G, Qi Q, Jiang S, Li J, Du L, Li F (2015) Receptor usage and cell entry of porcine epidemic diarrhea coronavirus … commercially (Genscript) … Get A Quote

摘要

Mammalian aminopeptidase N (APN) plays multifunctional roles in many physiological processes, including peptide metabolism, cell motility and adhesion, and coronavirus entry. Here we determined crystal structures of porcine APN at 1.85 Å resolution and its complexes with a peptide substrate and a variety of inhibitors. APN is a cell surface-anchored and seahorse-shaped zinc-aminopeptidase that forms head-to-head dimers. Captured in a catalytically active state, these structures of APN illustrate a detailed catalytic mechanism for its aminopeptidase activity. The active site and peptide-binding channel of APN reside in cavities with wide openings, allowing easy access to peptides. The cavities can potentially o... More

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