Galaxy银河|澳门官网·登录入口

至今,GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

Japanese Encephalitis Virus Vaccination Elicits Cross-Reactive HLA-Class I-Restricted CD8 T Cell Response Against Zika Virus Infection

Front Immunol. 2020; 
Marion Tarbe, Wei Dong, Guang Hu, Yongfen Xu, Jing Sun, Solene Grayo, Xianyang Chen, Chengfeng Qin, Jincun Zhao, Li Liu, Xiuzhen Li, Qibin Leng
Products/Services Used Details Operation
Peptide Synthesis … Peptide Synthesis. Peptides were synthesized by Genscript with a purity >95% confirmed by HPLC and mass spectrometry. All peptides were dissolved in DMSO at 10 mg/ml and stored at −20°C. Viruses, Cells, and Reagents … Get A Quote

摘要

Japanese encephalitis virus (JEV) exposure or vaccination could elicit cross-reactive CD8 T cell immunity against heterologous flaviviruses in humans. In addition, cross-reactive CD8 T cells induced by dengue virus (DENV) have been shown to play a protective role against Zika virus (ZIKV). However, how JEV exposure or vaccination affects ZIKV infection in humans remains unclear. In this report, epitope prediction algorithms were used to predict the cross-reactive CD8 T cell epitope restricted to human HLA between JEV and ZIKV. We found that these predicted CD8 T cell epitopes are immunogenic and cross-reactive in humanized HLA transgenic mice. Moreover, JEV vaccine immunization provided cross-protection against... More

关键词

CD8 T cells, HLA-A2 transgenic mice, JEV, Zika, cross-reactive, epitope, heterologous immunity
XML 地图