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Exploring functionality of the reverse β-oxidation pathway in Corynebacterium glutamicum for production of adipic acid

Microb Cell Fact. 2021-08; 
Jae Ho Shin, Aaron John Christian Andersen, Puck Achterberg, Lisbeth Olsson
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Gene Synthesis … glutamicum (Additional file 2: Table S2) and subsequent gene synthesis were carried out at GenScript (Piscataway, NJ, USA). All constructed vectors were sequence-verified at Eurofins Genomics or Macrogen Europe (Amsterdam, the Netherlands). Plasmid pZ8-Ptac (Addgene … Get A Quote

摘要

background: Adipic acid, a six-carbon platform chemical mainly used in nylon production, can be produced via reverse β-oxidation in microbial systems. The advantages posed by Corynebacterium glutamicum as a model cell factory for implementing the pathway include: (1) availability of genetic tools, (2) excretion of succinate and acetate when the TCA cycle becomes overflown, (3) initiation of biosynthesis with succinyl-CoA and acetyl-CoA, and (4) established succinic acid production. Here, we implemented the reverse β-oxidation pathway in C. glutamicum and assessed its functionality for adipic acid biosynthesis. results: To obtain a non-decarboxylative condensation product of acetyl-CoA and succinyl-CoA, and to... More

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