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Characterization of putative tachykinin peptides in Caenorhabditis elegans

Biochem Biophys Res Commun. 2021-05; 
Naoko Sakai, Hayao Ohno, Morikatsu Yoshida, Eri Iwamoto, Akito Kurogi, Danfeng Jiang, Takahiro Sato, Mikiya Miyazato, Masayasu Kojima, Johji Kato, Takanori Ida
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Gene Synthesis … expressing the full length of TKR-1 (NCBI Reference Sequence: NP_499064.2) was created by GenScript. The expression vector, TKR-1-pcDNA3.1, was transfected into Chinese hamster ovary (CHO) cells. Thereafter, cells stably expressing TKR-1 were selected using 1 mg/ml … Get A Quote

摘要

Tachykinin-like peptides, such as substance P, neurokinin A, and neurokinin B, are among the earliest discovered and best-studied neuropeptide families, and research on them has contributed greatly to our understanding of the endocrine control of many physiological processes. However, there are still many orphan tachykinin receptor homologs for which cognate ligands have not yet been identified, especially in small invertebrates, such as the nematode Caenorhabditis elegans (C. elegans). We here show that the C. elegans nlp-58 gene encodes putative ligands for the orphan G protein-coupled receptor (GPCR) TKR-1, which is a worm ortholog of tachykinin receptors. We first determine, through an unbiased biochemica... More

关键词

C. elegans, GPCR, Novel bioactive peptide, Tachykinin
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