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Persistence of immune responses to the Sinopharm/BBIBP-CorV vaccine

Immun Inflamm Dis. 2022-06; 
Chandima Jeewandara, Inoka Sepali Aberathna, Pradeep Darshana Pushpakumara, Achala Kamaladasa, Dinuka Guruge, Ayesha Wijesinghe, Banuri Gunasekera, Shyrar Tanussiya Ramu, Heshan Kuruppu, Thushali Ranasinghe, Shashika Dayarathna, Osanda Dissanayake, Nayanathara Gamalath, Dinithi Ekanayake, Jeewantha Jayamali, Deshni Jayathilaka, Madushika Dissanayake, Tibutius Thanesh Jayadas, Anushika Mudunkotuwa, Gayasha Somathilake, Michael Harvie, Thashmi Nimasha, Saubhagya Danasekara, Ruwan Wijayamuni, Lisa Schimanski, Pramila Rijal, Tiong K Tan, Tao Dong, Alain Townsend, Graham S Ogg, Gathsaurie Neelika Malavige
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Proteins, Expression, Isolation and Analysis … of VOCs in a subcohort of individuals (n = 110). The Svnt was carried out as previously described according to the manufacturer's instructions (Genscript Biotech). This measures the … Get A Quote

摘要

background: To determine the kinetics and persistence of immune responses following the Sinopharm/BBIBP-CorV, we investigated immune responses in a cohort of Sri Lankan individuals. methods: SARS-CoV-2 specific total antibodies were measured in 20-39 years (n = 61), 40-59 years (n = 120) and those >60 years of age (n = 22) by enzyme-linked immunosorbent assay, 12 weeks after the second dose of the vaccine. Angiotensin-converting enzyme 2 (ACE2) receptor blocking antibodies (ACE2R-Ab), antibodies to the receptor-binding domain (RBD) of the ancestral virus (WT) and variants of concern, were measured in a sub cohort. T cell responses and memory B cell responses were assessed by ELISpot assays. results... More

关键词

COVID-19, Sinopharm/BBIBP-CorV, antibody, kinetics, persistence, vaccines
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