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A dual cohesin-dockerin complex binding mode in Bacteroides cellulosolvens contributes to the size and complexity of its cellulosome

J Biol Chem. 2021-03; 
Marlene Duarte, Aldino Viegas, Victor D Alves, José A M Prates, Luís M A Ferreira, Shabir Najmudin, Eurico J Cabrita, Ana Luísa Carvalho, Carlos M G A Fontes, Pedro Bule
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Codon Optimization The genes encoding the two proteins were designed with a codon usage optimized to maximize expression in E. coli, synthesized in vitro (GenScript Ltd) Get A Quote

摘要

The Cellulosome is an intricate macromolecular protein complex that centralizes the cellulolytic efforts of many anaerobic microorganisms through the promotion of enzyme synergy and protein stability. The assembly of numerous carbohydrate processing enzymes into a macromolecular multiprotein structure results from the interaction of enzyme-borne dockerin modules with repeated cohesin modules present in noncatalytic scaffold proteins, termed scaffoldins. Cohesin-dockerin (Coh-Doc) modules are typically classified into different types, depending on structural conformation and cellulosome role. Thus, type I Coh-Doc complexes are usually responsible for enzyme integration into the cellulosome, while type II Coh-Doc... More

关键词

cellulase, cellulose, cellulosome, cohesin, crystal structure, dockerin, dual-binding, protein complex
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