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Voltage-gated ion channels are expressed in the Malpighian tubules and anal papillae of the yellow fever mosquito (Aedes aegypti), and may regulate ion transport during salt and water imbalance

J Exp Biol. 2024-02; 
Serena Farrell, Jocelyne Dates, Nancy Ramirez, Hannah Hausknecht-Buss, Dennis Kolosov
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Polyclonal Antibody Services The antiVGIC antibodies were custom-ordered from GenScript (Piscataway, NJ, USA), epitope-affinity purified and directed against the C-terminal region of the following Ae. aegypti proteins encoded by mRNA detected by RNAseq and PCR (NCBI accession no.; epitope): CaV1 alpha-1 isoform (XP_021699870.1; Get A Quote

摘要

Vectors of infectious disease include several species of Aedes mosquitoes. The life cycle of Aedes aegypti, the yellow fever mosquito, consists of a terrestrial adult and an aquatic larval life stage. Developing in coastal waters can expose larvae to fluctuating salinity, causing salt and water imbalance, which is addressed by two prime osmoregulatory organs - the Malpighian tubules (MTs) and anal papillae (AP). Voltage-gated ion channels (VGICs) have recently been implicated in the regulation of ion transport in the osmoregulatory epithelia of insects. In the current study, we: (i) generated MT transcriptomes of freshwater-acclimated and brackish water-exposed larvae of Ae. aegypti, (ii) detected expression of... More

关键词

Epithelia; Insect osmoregulation; Mosquito larvae; Vectors of infectious disease; Voltage-gated ion channels.
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