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Discovery and identification of a novel canine coronavirus causing a diarrhea outbreak in Vulpes

Sci Bull (Beijing). 2023-09; 
Yuting Liu, Yao Deng, Sheng Niu, Na Zhu, Jingdong Song, Xiaoshuang Zhang, Weiting Su, Wenhui Nie, Roujian Lu, David M Irwin, George Fu Gao, Wenling Wang, Qihui Wang, Wenjie Tan, Shuyi Zhang
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Molecular Biology Reagents … , synthesized (GenScript Biotech Corp., Piscataway, USA), and cloned in-frame with the Renilla luciferase gene (Rluc) and a Flag tag in the pcDNA 3.1 vector. Pseudovirions were … Get A Quote

摘要

Cross-species transmission of viruses from wildlife animal reservoirs, such as bats, poses a threat to human and domestic animal health. Previous studies have shown that domestic animals have important roles as intermediate hosts, enabling the transmission of genetically diverse coronaviruses from natural hosts to humans. Here, we report the identification and characterization of a novel canine coronavirus (VuCCoV), which caused an epidemic of acute diarrhea in Vulpes (foxes) in Shenyang, China. The epidemic started on November 8, 2019, and caused more than 39,600 deaths by January 1, 2022. Full-length viral genomic sequences were obtained from 15 foxes with diarrhea at the early stage of this outbreak. The VuC... More

关键词

Aminopeptidase N, Bat, Fox, Novel canine coronavirus, Pseudoviruses
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