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Modified mRNA Formulation and Stability for Cardiac and Skeletal Muscle Delivery

Pharmaceutics. 2023-08; 
Magdalena M Żak, Keerat Kaur, Jimeen Yoo, Ann Anu Kurian, Matthew Adjmi, Gayatri Mainkar, Seonghun Yoon, Lior Zangi
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Molecular Biology Reagents … Clean PCR products generated with plasmid templates, purchased from GenScript, were … , are suitable for efficient gene delivery in mammals. Non-modified mRNA causes increased … Get A Quote

摘要

Directly injecting naked or lipid nanoparticle (LNP)-encapsulated modified mRNA (modRNA) allows rapid and efficient protein expression. This non-viral technology has been used successfully in modRNA vaccines against SARS-CoV-2. The main challenges in using modRNA vaccines were the initial requirement for an ultra-cold storage to preserve their integrity and concerns regarding unwanted side effects from this new technology. Here, we showed that naked modRNA maintains its integrity when stored up to 7 days at 4 °C, and LNP-encapsulated modRNA for up to 7 days at room temperature. Naked modRNA is predominantly expressed at the site of injection when delivered into cardiac or skeletal muscle. In comparison, LNP-en... More

关键词

lipid nanoparticle-encapsulated mRNA, mRNA delivery, mRNA stability
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