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The Transcription Factor Ets1 Influences Axonal Growth via Regulation of Lcn2

Mol Neurobiol. 2023-09; 
Miao Gu, Xiaodi Li, Ronghua Wu, Xiao Cheng, Songlin Zhou, Xiaosong Gu
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Custom DNA/RNA Oligos … Specific primers were synthesized by Genscript … cells, Lcn2 siRNA was transfected into neuronal cells. qRT-PCR results showed reduced Lcn2 mRNA expression in neuronal cells … Get A Quote

摘要

Transcription factors are essential for the development and regeneration of the nervous system. The current study investigated key regulatory transcription factors in rat spinal cord development via RNA sequencing. The hub gene Ets1 was highly expressed in the spinal cord during the embryonic period, and then its expression decreased during spinal cord development. Knockdown of Ets1 significantly increased the axonal growth of cultured spinal cord neurons. Luciferase reporter assays and chromatin immunoprecipitation assays indicated that Ets1 could directly bind to the Lcn2 promoter and positively regulate Lcn2 transcription. In conclusion, these findings provide the first direct evidence that Ets1 regulates ax... More

关键词

Axon regeneration, Axonal growth, Ets1, Lcn2, Spinal cord development, Transcription factor
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