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A rapid nucleic acid detection platform based on phosphorothioate-DNA and sulfur binding domain

Synth Syst Biotechnol. 2023-02; 
Yuting Shuai, Yi Ju, Yuanhang Li, Dini Ma, Lan Jiang, Jingyu Zhang, Gao-Yi Tan, Xueting Liu, Shenlin Wang, Lixin Zhang, Guang Liu
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Proteins, Expression, Isolation and Analysis … (pET28a-luciferase) were ordered from GenScript (Nanjing, China) with sequence listed in supplementary note 1. All chemicals and reagents used were analytical grade and prepared … Get A Quote

摘要

Nucleic acid detection plays a key role in diverse diagnosis and disease control. Currently available nucleic acid detection techniques are challenged by trade-offs among speed, simplicity, precision and cost. Here, we described a novel method, designated SENSOR (Sulfur DNA mediated nucleic acid sensing platform), for rapid nucleic acid detection. SENSOR was developed from phosphorothioate (PT)-DNA and sulfur binding domain (SBD) which specifically binds double-stranded PT-modified DNA. SENSOR utilizes PT-DNA oligo and SBD as targeting module, which is linked with split luciferase reporter to generate luminescence signal within 10 min. We tested detection on synthesized nucleic acid and COVID-19 pseudovirus, a... More

关键词

Nucleic acid detection, Phosphorothioate, Sulfur binding domain
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