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In vitro antibody-mediated SARS-CoV-2 infection suppression through human ACE2 receptor blockade

Immunol Lett. 2024-06; 
Priscilla S Redd, Alyssa D Merting, John D Klement, Dakota B Poschel, Dafeng Yang, Kebin Liu
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Proteins, Expression, Isolation and Analysis … protein to immunize mice. Antisera from 5 mice were analyzed for affinity to ACE2 protein, … of rapid amplification of cDNA ends of GenScript. Amplified antibody fragments were cloned … Get A Quote

摘要

Vaccines and antibodies that specifically target or neutralize components of the SARS-CoV-2 virus are effective in prevention and treatment of human patients with SARS-CoV-2 infection. However, vaccines and SARS-CoV-2 neutralization antibodies target a subset of epitopes of viral proteins, and the fast evolution of the SARS-CoV-2 virus and the continuing emergence of SARS-CoV-2 variants confer SARS-CoV-2 immune escape from these therapies. ACE2 is the human cell receptor that serves as the entry point for SARS-CoV-2 into human cells and thus is the gatekeeper for SARS-CoV-2 infection of humans. We report here the development of 4G8C11, an anti-human ACE2 receptor monoclonal antibody that recognizes ACE2 on huma... More

关键词

4G8C11, ACE2, ACE2 blockade antibody, SARS-CoV-2
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