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Modification of Biomaterials with a Self-Protein Inhibits the Macrophage Response.

Adv Healthc Mater.. 2014-02;

YK Kim, R Que, SW Wang, WF Liu. Department of Biomedical Engineering, University of California, Irvine, CA, USA.

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摘要

A biomaterial that inhibits the host immune response by displaying an endo-genously expressed immunomodulatory molecule, CD200. Immobilization of CD200 onto biomaterial surfaces effectively suppresses macrophage activation and reduces inflammatory response to subcutaneously implanted materials.