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A KLHL40 3' UTR splice-altering variant causes milder NEM8, an under-appreciated disease mechanism
Authors: Lein N H Dofash, Gavin V Monahan, Emilia Servián-Morilla, Eloy Rivas, Fathimath Faiz, Patricia Sullivan, Emily Oates, Joshua Clayton, Rhonda L Taylor, Mark R Davis, Traude Beilharz, Nigel G Laing, Macarena Cabrera-Serrano, Gianina Ravenscroft
Journal: Hum Mol Genet
PubMed ID: 36322148
Doi: 10.1093/hmg/ddac272
Products & Services: Mammalian Expression   
Insulin stimulates atypical protein kinase C-mediated phosphorylation of the neuronal adaptor FE65 to potentiate neurite outgrowth by activating ARF6-Rac1 signaling
Authors: Dennis Dik-Long Chau, Wen Li, Wai Wa Ray Chan, Jacquelyne Ka-Li Sun, Yuqi Zhai, Hei-Man Chow, Kwok-Fai Lau
Journal: FASEB J
PubMed ID: 36250347
Doi: 10.1096/fj.202200757R
Products & Services: Proteins, Expression, Isolation and Analysis   
Trifluoro-icaritin ameliorates spared nerve injury-induced neuropathic pain by inhibiting microglial activation through α7nAChR-mediated blockade of BDNF/TrkB/KCC2 signaling in the spinal cord of rats
Authors: Dandan Jia, Guangsen Liu, Yalan Sun, Zhiping Hu, Zhihua Huang, Cheng Huang
Journal: Biomed Pharmacother
PubMed ID: 36375307
Doi: 10.1016/j.biopha.2022.114001
Products & Services: Recombinant Proteins   
Salidroside reduces neuropathology in Alzheimer's disease models by targeting NRF2/SIRT3 pathway
Authors: Yuyuan Yao, Zhichu Ren, Ruihan Yang, Yilan Mei, Yuying Dai, Qian Cheng, Chong Xu, Xiaogang Xu, Sanying Wang, Kyoung Mi Kim, Ji Heon Noh, Jian Zhu, Ningwei Zhao, Yong U Liu, Genxiang Mao, Jian Sima
Journal: Cell Biosci
PubMed ID: 36333711
Doi: 10.1186/s13578-022-00918-z
Products & Services: Custom DNA/RNA Oligos   
How modular protein nanoparticles may expand the ability of subunit anti-viral vaccines: The spring viremia carp virus (SVCV) case
Authors: Mauricio Rojas, Patricia Aceituno, Maria E Salvador, Marlid Garcia-Ordoñez, Mariana Teles, Maria Del Mar Ortega-Villaizan, Luis Perez, Nerea Roher
Journal: Fish Shellfish Immunol
PubMed ID: 36371050
Doi: 10.1016/j.fsi.2022.10.067
Products & Services: Proteins, Expression, Isolation and Analysis   
Alveolar epithelial cells and microenvironmental stiffness synergistically drive fibroblast activation in three-dimensional hydrogel lung models
Authors: Thomas Caracena, Rachel Blomberg, Rukshika S Hewawasam, Zoe E Fry, David W H Riches, Chelsea M Magin
Journal: Biomater Sci
PubMed ID: 36366982
Doi: 10.1039/d2bm00827k
Products & Services: Peptide Synthesis   
speedingCARs: accelerating the engineering of CAR T cells by signaling domain shuffling and single-cell sequencing
Authors: Rocío Castellanos-Rueda, Raphaël B Di Roberto, Florian Bieberich, Fabrice S Schlatter, Darya Palianina, Oanh T P Nguyen, Edo Kapetanovic, Heinz Läubli, Andreas Hierlemann, Nina Khanna, Sai T Reddy
Journal: Nat Commun
PubMed ID: 36323661
Doi: 10.1038/s41467-022-34141-8
Products & Services: Proteins, Expression, Isolation and Analysis   
Discovery and mechanism of action of Thonzonium bromide from an FDA-approved drug library with potent and broad-spectrum inhibitory activity against main proteases of human coronaviruses
Authors: Ruyu Wang, Guanglei Zhai, Guanghao Zhu, Mengge Wang, Xiaoyi Gong, Weidong Zhang, Guangbo Ge, Hongzhuan Chen, Lili Chen
Journal: Bioorg Chem
PubMed ID: 36395603
Doi: 10.1016/j.bioorg.2022.106264
Products & Services: Gene Synthesis   
Mammalian Target of Rapamycin Inhibition Decreases Angiotensin II-Induced Steroidogenesis in HAC15 Human Adrenocortical Carcinoma Cells
Authors: Yusuf Ali, Elise P Gomez-Sanchez, Celso E Gomez-Sanchez
Journal: Endocrinology
PubMed ID: 36320101
Doi: 10.1210/endocr/bqac185
Products & Services: Gene Synthesis   
Linoleic acid binds to SARS-CoV-2 RdRp and represses replication of seasonal human coronavirus OC43
Authors: Anna Goc, Waldemar Sumera, Matthias Rath, Aleksandra Niedzwiecki
Journal: Sci Rep
PubMed ID: 36352079
Doi: 10.1038/s41598-022-23880-9
Products & Services: DNA Sequencing   
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