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Chlorovirus Skp1-binding Ankyrin-Repeat Protein Interplay and Mimicry of Cellular Ubiquitin Ligase Machinery.

J Virol.. 2014-09; 
EA Noel, M Kang, J Adamec, JL Van Etten, GA Oyler. Dept. of Plant Pathology, University of Nebraska, Lincoln, NE 68583-0900.
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摘要

The ubiquitin-proteasome system is targeted by many viruses that have evolved strategies to redirect host ubiquitination machinery. Members of the genus Chlorovirus are proposed to share a common ancestral lineage with a broader group of related viruses, Nucleo-Cytoplasmic Large DNA Viruses (NCLDV). Chloroviruses encode a Skp1 homolog and ankyrin-repeat (ANK) proteins. Several chlorovirus encoded ANK-repeats contain C-terminal domains characteristic of cellular F-boxes or related NCLDV chordopox PRANC domains. These observations suggested that this unique combination of Skp1 and ANK-repeat proteins might form complexes analogous to the cellular Skp1-Cul1-F-box (SCF) ubiquitin ligase complex. We identified two A... More

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