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Gonococcal MtrE and its surface-expressed Loop 2 are immunogenic and elicit bactericidal antibodies

J. Infect.. 2018-09; 
WangShuyi，XueJuan，LuPing，NiChunshan，ChengHao，HanRui，van der VeenS
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Peptide Synthesis … hour. After washing with PBS-T, membranes were incubated for one hour at room temperature with polyclonal antibodies raised in rabbits against the MtrE Loop 2 peptide (antibodies and peptide produced by Genscript). Membranes … Get A Quote

摘要

The rise in multidrug resistant Neisseria gonorrhoeae poses a threat to healthcare， while the development of an effective vaccine has remained elusive due to antigenic and phase variability of surface-expressed proteins. In the current study， we identified a fully conserved surface expressed protein and characterized its suitability as a vaccine antigen.

关键词

C4bp，Epitope display，IMX315，Loop 2，MtrCDE，MtrE，Neisseria gonorrhoeae，SBA，Vac
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