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Critical and direct involvement of the CD23 stalk region in IgE binding

J. Allergy Clin. Immunol.. 2017-01;

SelbRegina, Eckl-DornaJulia, TwarochTeresa E, LupinekChristian, TeufelbergerAndrea, HoferGerhard, Focke-TejklMargarete, GeppBarbara, LinhartBirgit, BreitenederHeimo, EllingerAdolf, KellerWalter, RouxKenneth H, ValentaRudolf, NiederbergerVe

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摘要

The low-affinity receptor for IgE， FcεRII (CD23)， contributes to allergic inflammation through allergen presentation to T cells， regulation of IgE responses， and enhancement of transepithelial allergen migration.