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Selectin-Targeting Peptide-Glycosaminoglycan Conjugates Modulate Neutrophil-Endothelial Interactions.

Cell Mol Bioeng. 2019; 
WodickaJames R，MorikisVasilios A，DehghaniTima，SimonScott I，PanitchAl
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Peptide Synthesis … 26 Briefly, vicinal diol groups on DS (MW avg 46,275 Da, Celsus Laboratories, Cincinnati, OH) were oxidized to aldehydes using sodium meta … a 1:1 molar ratio of biotinylated peptide:DS and an excess of the selectin-binding peptide IELLQARGC (IEL, Genscript, Piscataway, NJ … Get A Quote

摘要

The glycocalyx is a layer of glycoproteins， proteoglycans and glycosaminoglycans that coats the luminal surface of most blood vessels. It effectively regulates adhesive interactions between leukocytes in flowing blood and the endothelium， where during inflammation， binding to E- and P-selectins and intercellular adhesion molecule-1 (ICAM-1) promotes cell tethering and arrest under shear flow.

关键词

Endothelial dysfunction，Glycocalyx，Glycosaminoglycan，Neutrophil，Sele
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