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Microrheology of interphase chromosomes with spatial constraints: A computational study.

Phys Biol. 2019-08; 
PapaleAndrea,RosaAn
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摘要

Chromatin fibers within the interior of the nucleus of the cell make stable interactions with the nucleoskeleton, an ensemble of ``extra-chromatin'' structures which help ensuring genome stability. Although the role of these interactions appears crucial to the correct behavior of the cell, their impact on chromatin structure and dynamics remains to be elucidated. In order to tackle this important issue, in this work we introduce a simple polymer model for chromatin fibers in interphase which takes into account the two generic properties of chain-vs.-chain mutual uncrossability and the presence of stable binding interactions to an extra-chromatin nuclear matrix. To study how these constraints affect chroma... More

关键词

Chromosome organization,Diffusion,Microrheology,Polymer phy
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