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Surface-Modified Melphalan Nanoparticles for Intravitreal Chemotherapy of Retinoblastoma.

Invest Ophthalmol Vis Sci. 2019-04; 
SimsLee B，TyoKevin M，StockeSanaya，MahmoudMohamed Y，RamasubramanianAparna，Steinbach-RankinsJi
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Peptide Synthesis … A similar protocol was followed to synthesize NPs modified with the biotinylated peptides: MPG (3177 Da, GenScript, Piscataway, NJ, USA), PEG (5000 Da, Nanocs Inc.), and TET1 (1873 Da, GenScript), with the addition of avidin palmitate (1 mg/mL) to the 5% PVA solution (Fig … Get A Quote

摘要

The goal of this work was to design and assess the ability of unmodified and surface-modified poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) to enhance cell association， provide efficacy in retinoblastoma cells， and overcome current administration challenges， including hydrolysis and precipitation， of intravitreal administration.

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