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Pim-1 Kinase Phosphorylates Cardiac Troponin I and Regulates Cardiac Myofilament Function.

Cell. Physiol. Biochem.. 2018;

Zhu Ni，Yi Bing，Guo Zhifu，Zhang Guanxin，Huang Shengdong，Qin Yongwen，Zhao Xianxian，Sun Jia

Products/Services Used	Details	Operation
Peptide Synthesis	. For western blot analysis, recombinant cTnI ATP (500 μmol/L). by Genscript. Peptides were incubated	Get A Quote

摘要

Pim-1 is a serine/threonine kinase that is highly expressed in the heart， and exerts potent cardiac protective effects through enhancing survival， proliferation， and regeneration of cardiomyocytes. Its myocardial specific substrates， however， remain unknown. In the present study， we aim to investigate whether Pim-1 modulates myofilament activity through phosphorylation of cardiac troponin I (cTnI)， a key component in regulating myofilament function in the heart.