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Immunogenicity and efficacy of replication-competent recombinant influenza virus carrying multimeric M2 extracellular domains in a chimeric hemagglutinin conjugate.

Antiviral Res. 2017;

Kim MC, Lee YN, Kim YJ, Choi HJ, Kim KH, Lee YJ, Kang SM.

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Peptide Synthesis	… 1A) was designed and synthesized (Genscript) to be inserted between the HA signal peptide sequence and N-terminal domain of the HA1 ectodomain (M2e4x-HA) of wild-type A/PR8 virus (Fig. 1A) using a previous strategy by Li et al. (2005) …	Get A Quote

摘要

Current influenza vaccines provide hemagglutinin (HA) strain-specific protection. To improve cross protection, we engineered replication-competent influenza A virus to express tandem repeats of heterologous M2 extracellular (M2e) domains in a chimeric HA. M2e epitopes conjugated to HA glycoproteins (M2e4x-HA) were found to be expressed on the surfaces of a replicable influenza virus as examined by electron microscopy. The recombinant influenza virus containing M2e4x-HA was moderately attenuated but superior to the parental virus in inducing M2e specific antibodies without compromising HA immunogenicity. Recombinant influenza virus immune mice showed better cross protection than parental virus immune mice. Immun... More