| Products/Services Used | Details | Operation |
|---|---|---|
| Peptide Synthesis | … CAA59793.1, -70-). The amino acid sequences of the peptides used are shown in Table 1. These peptides and the Hsp70 protein were purchased from GenScript (Piscataway, NJ, USA). The vaccination schedule consisted … | Get A Quote |
HisAK70 candidates have successfully been tested in cutaneous (CL) and visceral leishmaniosis (VL) mouse models. Here, we analyse different biomarkers in dog trials after a heterologous immunization strategy with a HisAK70 candidate (plasmid DNA plus adoptive transfer of peripheral blood-derived dendritic cells (DCs) pulsed with the same pathoantigen and CpG ODN as an adjuvant) to explore the antileishmanial activity in an ex vivo canine co-culture system in the presence of Leishmania infantum parasites. In the canine model, the heterologous HisAK70 vaccine could decrease the infection index in the DC-T cell co-culture system by up to 54% after 30 days and reach almost 67% after 100 days post-immunization, resp... More
