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Modified gaphene oxide (GO) particles in peptide hydrogels: a hybrid system enabling scheduled delivery of synergistic combinations of chemotherapeutics

J Mater Chem B. 2020-05-01; 
John D Schneible, Kaihang Shi, Ashlyn T Young, Srivatsan Ramesh, Nanfei He, Clay E Dowdey, Jean Marie Dubnansky, Radina L Lilova, Wei Gao, Erik Santiso, Michael Daniele, Stefano Menegatti
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Peptide Synthesis … Woburn, MA). The Max8 peptide (VKVKVKVKV D PPTKVEVKVKV-NH 2 ), 63,74,75 where D P represents D-Proline and –NH 2 indicates an amidated C-terminus, was obtained from Genscript (Nanjing, China) at >95% purity. 1,1 … Get A Quote

摘要

The scheduled delivery of synergistic drug combinations is increasingly recognized as highly effective against advanced solid tumors. Of particular interest are composite systems that release a sequence of drugs with defined kinetics and molar ratios to enhance therapeutic effect, while minimizing the dose to patients. In this work, we developed a homogeneous composite comprising modified graphene oxide (GO) nanoparticles embedded in a Max8 peptide hydrogel, which provides controlled kinetics and molar ratios of release of doxorubicin (DOX) and gemcitabine (GEM). First, modified GO nanoparticles (tGO) were designed to afford high DOX loading and sustained release (18.9% over 72 h and 31.4% over 4 weeks). Molecu... More

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