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Lnc-PFAR facilitates autophagy and exacerbates pancreatic fibrosis by reducing pre-miR-141 maturation in chronic pancreatitis

Cell Death Dis. 2021-10; 
Tao Zhang, Guangquan Zhang, Wenbo Yang, Hongze Chen, Jisheng Hu, Zhongjie Zhao, Chundong Cheng, Guanqun Li, Yu Xie, Yilong Li, Rui Kong, Yongwei Wang, Gang Wang, Hua Chen, Xue-Wei Bai, Shangha Pan, Bei Sun, Le Li
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Gene Synthesis The pcDNA3.1-Lnc-PFAR was obtained from GenScript (Nanjing, China) Get A Quote

摘要

Chronic pancreatitis (CP) is described as progressive inflammatory fibrosis of pancreas, accompanied with irreversible impaired endocrine and exocrine insufficiency. Pancreatic stellate cells (PSCs) are widely distributed in the stroma of the pancreas and PSCs activation has been shown as one of the leading causes for pancreatic fibrosis. Our previous study has revealed that autophagy is dramatically activated in CP tissues, which facilitates PSCs activation and pancreatic fibrosis. Long non-coding RNAs (LncRNAs) have been recognized as crucial regulators for fibrosis-related diseases. LncRNAs interact with RNA binding protein or construct competitive endogenous RNA (ceRNA) hypothesis which elicited the fibroti... More

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