• 抗原物种:
  Human
• 描述
  The P2Y receptor 12 (P2Y12) is a Gi-coupled GPCR expressed in platelets, brain tissues, vascular smooth muscle cells. P2Y12 can sustain platelet aggregation and promote thrombus growth and stabilization. It also plays a function in dense and alpha granule secretion, p-selectin expression and microparticle formation.
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• 描述
  Recombinant CHO-K1 cells stably overexpress low affinity immunoglobulin gamma Fc region receptor III-A (FcγRIIIa / CD16A 158F) complex on the cell surface, including 1 alpha chain and 2 gamma chains. The surface expression of CD16A is validated by FACS analysis. This stable cell line product is designed for measuring binding affinity and stability of the Fc region of antibodies, Fc fusion proteins, or antibody based biologics that bind with CD16A 158F. GenScript also offers a stable cell line expressing the CD16A of 158V allotype (Cat. No. M00597) for FcγRIIIa polymorphism study.
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  [2 Images]

• 描述
  Recombinant CHO-K1 cells stably express low affinity immunoglobulin gamma Fc region receptor III-A (FcγRIIIa / CD16A 158V) complex on the cell surface, including 1 alpha chain and 2 gamma chains. The surface expression of CD16A is validated by FACS analysis. This stable cell line product is designed for measuring the binding affinity and stability of the Fc region of antibodies, Fc fusion proteins, or antibody based biologics that bind with CD16A 158V. GenScript also offers a stable cell line expressing the CD16A of 158F allotype (Cat. No. M00598) for FcγRIIIa polymorphism study.
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  [1 Image]

• 描述
  PEP-1 peptide, which has 21 amino acid residues, is a known carrier peptide that delivers full-length native proteins in vitro and in vivo. Pep-1 peptide, consists of three domains: (1) a hydrophobic tryptophan-rich motif containing five tryptophan residues (KETW WETWWTEW); (2) a hydrophilic lysine-rich domain (KKKRKV) derived from the nuclear localization sequence (NLS) of simian virus 40 (SV-40) large T antigen; and (3) a spacer domain (SQP), separating the two domains mentioned above, containing a proline residue, which improves the flexibility and the integrity of both the hydrophobic and the hydrophilic domains. In standard cell culture conditions, Pep-1 localizes rapidly, in
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1 Citations

• 应用:
  ELISA; FCM; sVNT;
• 亚型:
  Mouse IgG1,κ
• 偶物联:
  Unconjugated
• 免疫原:
  Recombinant SARS-CoV-2 Spike protein fragment
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  [2 Images]

• 同义词:
  GS-PepFirming™ Dipeptide Diaminobutyroyl Benzylamide Diacetate Stock Solution
• 描述
  Dipeptide Diaminobutyroyl Benzylamide Diacetate Stock Solution

1 Citations

• 抗原物种:
  Human
• 描述
  The ß-adrenergic receptors are linked to G proteins. The ß-receptor has three known subtypes. Beta-1 receptors primarily regulate myocardial tissue and affect the rate of contraction via impulse conduction. Beta-2 receptors regulate smooth muscle tone and influence vascular and bronchiolar relaxation. Beta-3 receptors are less well studied but are thought to primarily affect lypolysis and may have effects on cardiac inotropy (Greene Shepherd，2006). In the human heart, beta (1)- and beta (2)AR are the most powerful physiologic mechanism to acutely increase cardiac performance. Changes in betaAR play an important role in chronic heart failure (CHF). Thus, due to increased sympathetic activity in CHF, betaAR are chronically (over) stimulated, and that results in beta (1) AR desensitization and alterations of down-stream mechanisms (Brodde OE，2006).
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  [2 Images]

• 应用:
  WB; ELISA;
• 亚型:
  Mouse IgG1,κ
• 偶物联:
  Horseradish peroxidase (HRP)
• 免疫原:
  NWSHPQFEK peptide conjugated to KLH
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  [2 Images]

• 抗原物种:
  Human
• 描述
  Adrenoceptors are 7-transmembrane receptors which mediate the central and peripheral actions of the neurotransmitter, noradrenaline (norepinephrine), and the hormone and neurotransmitter, adrenaline (epinephrine). Based on both pharmacological and molecular evidence, they are divided into three major types - α1, α2, and β. The α2 adrenoceptors include 3 subtypes - α2A, α2B, and α2C - each of which couples to Gi/o protein primarily. The α2B adrenoceptors (ADRA2B) is expressed in the kidney, liver, brain, lung, heart, and skeletal muscle. The development of α2B and α2C knock-out mice has shown that these two subtypes are not involved in the central hypotensive response to α2 agonists.
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• 抗原物种:
  human
• 描述
  CD38 (cluster of differentiation 38), also known as cyclic ADP ribose hydrolase is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B lymphocytes and natural killer cells. CD38 also functions in cell adhesion, signal transduction and calcium signaling. In humans, the CD38 protein is encoded by the CD38 gene which is located on chromosome 4. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2+.
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